Canine DNA breed tests

[DogsAndTheMob]

https://www.cbc.ca/news/business/marketplace-dog-dna-test-1.6763274?f

 

Results of submitting DNA samples from two mixed breed/no breed dogs, one purebred Great Dane and one human for canine breed DNA testing.

[Mairead]

Same as with DNA tests for human ancestry, the results change as the database changes eg people with Aboriginal ancestry will get results from the USA database which include "unknown". On those websites that update your results, people have found that their Basque ancestry disappears when more samples are added to the database. The finding of relatives, however, is apparently reasonably accurate.

But for a mixed breed dog, why does DNA matter? I would be asking "who does the dog believe itself to be?" - mostly sighthound, terrier, herding dog? 

[asal]

far as I am concerned its a total waste of money, far better spent on dna profiling for genetic disorders so you at least know what your dog is clear for or has and if its been unlucky at least plan for how to address the affects of the known results of discovering your dog is C for Pra, PLL or any of the other genes that will keep your vet living well financially, instead of you.

for example if you have a border collie or has border collie in it click on each name to see what it can inherit and the results of that.  Click on "back to breed profiles "  to check out the breed or breeds your dog is and the little surprises your dogs breed can be hiding. 

 

https://www.orivet.com/store/canine-full-breed-profile/border-collie---full-breed-profile

 

Like this little number of example, but as a good salesman will tell you, "but theres more." 

Trapped Neutrophil Syndrome (Border Collie Type)

 

TEST OVERVIEW:

This is an autosomal recessive disease of Border Collies that appears to have been present in the breed for a very long time, and occurs across all lines. It is an immune defect where neutrophils are produced by the bone marrow, but there is a defect that prevents their release into the bloodstream. This results in a susceptibility to infection and tendency to ill-thrift and repeated infections. Some pups are small and fine-boned in appearance, while others appear normal. Pups will often react badly to vaccination, developing severe fever and illness. Most affected animals die or are euthanised by the age of 6 months. Affected animals are diagnosed by having a low neutrophil count on blood tests, but plentiful neutrophils on bone marrow biopsy. A DNA test is now available so that breeding animals may be tested and carrier animals detected. It is estimated that 10 – 15% of the Border collie population are carriers for trapped neutrophil syndrome. There is no cure for this disease.

CATEGORY:

Immunologic - Associated with the organs and cells of the immune system

GENE:

Vacuolar protein sorting 13 homolog B (VPS13B) on Chromosome 13

VARIANT DETECTED:

Nucleotide Deletion CanFam 2.1 (g.4411956_4411960delGTTT)

SEVERITY:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

MODE OF INHERITANCE:

Autosomal Recessive

RECOMMENDED SCREENING:

1. DNA screening of all breeding animals prior to breeding (e.g. at 1 year of age).

RESEARCH CITATION(S):

Shearman, JR. et al. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. (2011) BMC Genomics 12;258.

ASSOCIATED BREED(S):

Border Collie, Koolie , Mixed Breed,

 

check them all out.   so being told a list of possible breeds doesn't warn you, your dog may go deaf, blind or dead before it 4 years if it gets the short straw.  why breeders who dna profile their breeding dogs as where you should be shopping .   adopting is a complete gamble when you know zilch about the parents dna profiles?

 

 

 

Edited March 9, 2023 by asal

[sandgrubber]

I'd say Embark did well.  The article would have been more useful if the samples submitted were from mutts coming from regions dominated by breeds recognised by kennel clubs and mixtures of such breeds.  The companies should probably add a disclaimer saying their model was created using dogs from such and such a region, and their confidence in results is lower if the dog came from regions including land races not included in the creation of their model.

[persephone]

21 hours ago, DogsAndTheMob said:

https://www.cbc.ca/news/business/marketplace-dog-dna-test-1.6763274?f

 

Results of submitting DNA samples from two mixed breed/no breed dogs, one purebred Great Dane and one human for canine breed DNA testing.

fascinating ! 

 

[moosmum]

I like Embark because it  tests extensively for health and results/information provided assists in further research.

[sandgrubber]

On 09/03/2023 at 5:52 PM, asal said:

far as I am concerned its a total waste of money, far better spent on dna profiling for genetic disorders so you at least know what your dog is clear for or has and if its been unlucky at least plan for how to address the affects of the known results of discovering your dog is C for Pra, PLL or any of the other genes that will keep your vet living well financially, instead of you.

for example if you have a border collie or has border collie in it click on each name to see what it can inherit and the results of that.  Click on "back to breed profiles "  to check out the breed or breeds your dog is and the little surprises your dogs breed can be hiding. 

 

https://www.orivet.com/store/canine-full-breed-profile/border-collie---full-breed-profile

 

Like this little number of example, but as a good salesman will tell you, "but theres more." 

Trapped Neutrophil Syndrome (Border Collie Type)

 

TEST OVERVIEW:

This is an autosomal recessive disease of Border Collies that appears to have been present in the breed for a very long time, and occurs across all lines. It is an immune defect where neutrophils are produced by the bone marrow, but there is a defect that prevents their release into the bloodstream. This results in a susceptibility to infection and tendency to ill-thrift and repeated infections. Some pups are small and fine-boned in appearance, while others appear normal. Pups will often react badly to vaccination, developing severe fever and illness. Most affected animals die or are euthanised by the age of 6 months. Affected animals are diagnosed by having a low neutrophil count on blood tests, but plentiful neutrophils on bone marrow biopsy. A DNA test is now available so that breeding animals may be tested and carrier animals detected. It is estimated that 10 – 15% of the Border collie population are carriers for trapped neutrophil syndrome. There is no cure for this disease.

CATEGORY:

Immunologic - Associated with the organs and cells of the immune system

GENE:

Vacuolar protein sorting 13 homolog B (VPS13B) on Chromosome 13

VARIANT DETECTED:

Nucleotide Deletion CanFam 2.1 (g.4411956_4411960delGTTT)

SEVERITY:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

MODE OF INHERITANCE:

Autosomal Recessive

RECOMMENDED SCREENING:

1. DNA screening of all breeding animals prior to breeding (e.g. at 1 year of age).

RESEARCH CITATION(S):

Shearman, JR. et al. A canine model of Cohen syndrome: Trapped Neutrophil Syndrome. (2011) BMC Genomics 12;258.

ASSOCIATED BREED(S):

Border Collie, Koolie , Mixed Breed,

 

check them all out.   so being told a list of possible breeds doesn't warn you, your dog may go deaf, blind or dead before it 4 years if it gets the short straw.  why breeders who dna profile their breeding dogs as where you should be shopping .   adopting is a complete gamble when you know zilch about the parents dna profiles?

 

 

 

I have two problems with genetic profiling related to health

1. It's not regulated or patrolled AT ALL.  There's nothing to prevent inaccurate results or inaccurate descriptions.  

2. Prevalence is rarely reported, and testing for genes known to be part of the cause for polygenetic conditions (eg hip/elbow dysplasia) are hard to use effectively.  The companies tend to spew out results on things they can test for, no matter how rare (eg narcolepsy) while providing little helpful information on common problems (eg allergies, temperament faults).

 

Yes, do the testing, but don't let it fool you into thinking it's a recipe for breeding healthy dogs, and beware of false readings.

[asal]

On 11/03/2023 at 7:37 AM, sandgrubber said:

I have two problems with genetic profiling related to health

1. It's not regulated or patrolled AT ALL.  There's nothing to prevent inaccurate results or inaccurate descriptions.  

2. Prevalence is rarely reported, and testing for genes known to be part of the cause for polygenetic conditions (eg hip/elbow dysplasia) are hard to use effectively.  The companies tend to spew out results on things they can test for, no matter how rare (eg narcolepsy) while providing little helpful information on common problems (eg allergies, temperament faults).

 

Yes, do the testing, but don't let it fool you into thinking it's a recipe for breeding healthy dogs, and beware of false readings.

 

Very good points.

So many of the tests done are for traits the majority of dogs never come up positive for anyway, just gives a classier looking list of "clear for" ,

 

But! some if present can end in blindness, deafness and/or death  at an early age.

 

Knowing that is a help in prevention in your breeding program.

As well , In managing the future of  your new or old pet if you have it profiled and learn it carries any, if you bought it from a breeder who has not had a profile done of the parents, which probably accounts for the majority of dogs "adopted" or "shopped" from the majority of dogs actually bred in this country.

Since so few are actually bred by breeders who do have their breeding dogs profiled.  As was finally brought to light by this brilliant research done in 2016.  Wonder what the pie chart would reveal for 2022?

 

https://ankc.org.au/media/6598/a-forensic-view-of-puppy-breeding-in-australiav4.pdf

 

As for the "breed profiles"  so many are having done to find out what breeds are in their dog? May as well just throw in a card for each breed and pull out a card or cards yourself .

 

anyone that doubts that, they come so unstuck when they cant even get the so called ancestry of identical twins to match !

Edited March 12, 2023 by asal