GeorgieB Posted August 29, 2012 Share Posted August 29, 2012 Hi guys :) I recently got Reggie tested for the MDR1 gene mutation (ivemectin sensitivity) and just got the results back now and she is a Carrier only. I've heard conflicting ideas on weather carriers still react to ivermectin and related drugs or not. Does anyone know for certain? Link to comment Share on other sites More sharing options...
Dame Aussie Posted August 29, 2012 Share Posted August 29, 2012 (edited) Gosh I don't remember off the top of my head! I think they can still be sensitive but not as much? This link has a lot of info though :) http://www.ashgi.org/articles/mdr1.htm I haven't had Lili tested, I just avoid any of the drugs anyway to be safe. ETA: out of interest, who did you test through? Gribbles? Edited August 29, 2012 by Aussie3 Link to comment Share on other sites More sharing options...
GeorgieB Posted August 29, 2012 Author Share Posted August 29, 2012 (edited) Cheers for that Aussie3, that does say that carriers should be considered sensitive too. I got the test though GTG Labs for $75 ($71 if you pay online I think) ETA: I was planning to avoid the drugs too anyway, just would have been nice to not have to stress to the vets everytime she's in for something :laugh: Edited August 29, 2012 by GeorgieB Link to comment Share on other sites More sharing options...
Dame Aussie Posted August 29, 2012 Share Posted August 29, 2012 That's not bad actually, I should really tear, but Ive always been so paranoid I've treated her as if she was affected her whole life anyway :laugh: You may find that not all vets are very familiar with the mutation too so make sure you give them a list of the meds if she's ever getting anything done, only a couple I've been to really knew what it was! Link to comment Share on other sites More sharing options...
GeorgieB Posted August 29, 2012 Author Share Posted August 29, 2012 That's good advice Aussie3, Thankfully my vet is aware of the condition (Asked him before I even brought Reggie home). But if she has to go in for anything I sure will be reminding him!! :p Link to comment Share on other sites More sharing options...
Dxenion Posted August 29, 2012 Share Posted August 29, 2012 One of ours is a carrier and hasn't shown any reaction to any of the import vaccinations or local ones. I did request the vet put it on record just in case. Link to comment Share on other sites More sharing options...
wuffles Posted August 29, 2012 Share Posted August 29, 2012 As far as I know there is evidence that some carriers also show symptoms. I would avoid the drugs just in case. I had my girl tested (the most she could be was a carrier anyway) but she came back clear :) Link to comment Share on other sites More sharing options...
Kia Posted August 29, 2012 Share Posted August 29, 2012 Hi GeorgieB I have had aussies since 1999 and was lucky as I put the early ones on heartworm meds. I didn't even know about it back then and didn't have a computer. Although these days I test and know the MDR1 status of my dogs I still don't give them heartworm meds. If you google heartworms you will find plenty of info and the conditions that are needed for mozzies to transfer the microfilae. I did have one MDR1 carrier that didn't handle a desexing surgery well....she wouldn't drink for over 12 hours and wouldn't eat for nearly 24 hours. The medications were not on the list to be avoided so we assume she just was one of those dogs that didn't do well with anesthetics. These days all of mine that go in for anything that has the dog put under gets extra fluids to help flush it out of the system quicker. I have desexed affected with no complications doing it this way. Give the vet the list of problem drugs and have it put on the pups records. Link to comment Share on other sites More sharing options...
Sayly Posted August 30, 2012 Share Posted August 30, 2012 I have a carrier and a clear here, and I keep clear of the drugs for the carrier. I print this out and give it to my vets: http://miniaussierescue.org/BusterAlert/MDR1VetFactSheetLK9-8-07.doc Link to comment Share on other sites More sharing options...
Dxenion Posted August 30, 2012 Share Posted August 30, 2012 Thanks for the link Sayly. I'll print this off for our own and the vet's records. Link to comment Share on other sites More sharing options...
karly101 Posted August 30, 2012 Share Posted August 30, 2012 Mine is a carrier - a lot of the drugs listed are safe in normal usage and at higher levels they can be toxic. I just gave my vet this list - http://www.vetmed.wsu.edu/depts-vcpl/drugs.aspx I did the test as I used Advocate at higher doses than normal when my boy had demodex. No problems, he went through surgery okay as well and is on cyclosporine with no issues thus far. One vet almost prescribed my boy flagyl which isn't recommended so its always a good idea to look up any drugs prescribed. Link to comment Share on other sites More sharing options...
GeorgieB Posted August 30, 2012 Author Share Posted August 30, 2012 Thanks guys, I'll definitely print out that link too Sayly thanks! Link to comment Share on other sites More sharing options...
InspectorRex Posted August 30, 2012 Share Posted August 30, 2012 Hi GeorgieB We have Rough Collies(since 1960). They are DNA "affected" for MDR1-Ivermectin. On the research I have done I wouldn't give Ivermectin or related drugs even to a Carrie. Also do you have the list of other medications that should not be given to affected/carriers due to the neuro toxicity? If you havent please feel free to email me at [email protected] and I will email it to you. I take the list with me when I have to take my dogs to the Vet. my regular Vet has it all on file and it well versed with MDR1 sensitivity. Link to comment Share on other sites More sharing options...
Dame Aussie Posted August 31, 2012 Share Posted August 31, 2012 Hi GeorgieB We have Rough Collies(since 1960). They are DNA "affected" for MDR1-Ivermectin. On the research I have done I wouldn't give Ivermectin or related drugs even to a Carrie. Also do you have the list of other medications that should not be given to affected/carriers due to the neuro toxicity? If you havent please feel free to email me at [email protected] and I will email it to you. I take the list with me when I have to take my dogs to the Vet. my regular Vet has it all on file and it well versed with MDR1 sensitivity. Can I email you for this too please inspector Rex? Link to comment Share on other sites More sharing options...
GeorgieB Posted August 31, 2012 Author Share Posted August 31, 2012 Thanks InspectorRex Link to comment Share on other sites More sharing options...
Kia Posted August 31, 2012 Share Posted August 31, 2012 http://www.vetmed.wsu.edu/depts-VCPL/ here is a link to the information that i send out with all puppy purchasers. Link to comment Share on other sites More sharing options...
Elwira Posted September 2, 2012 Share Posted September 2, 2012 I have rough collies, most free and some carriers. But my vet says (actually 3 vets have a similar opinion) that collies are very sensitive race, and all are sensitive to the drugs from MDR1 list and other (outside the list). So when I come with a MDR1 DNA free dog he is treated as a affected :-) I don't know how looks the situation in your breed (Aussie), rough collies are quite strongly related (average inbreeding 13%) so they can be more sensitive. Anyway I read article and in laboratory tests, animals (probably mice, but I don't remember) were sensitive to varying degrees: affected (-/-) already reacted to the minimum dose, carriers (+/-) have a higher tolerance, free (+/+) have a high tolerance. But of course overdose will be dangerous for any dog. So I suppose that MDR1 carrier dog is more sensitive as free dog, but not so much as affected dog. Alternative medicines are available so it's better to use them. I hope my English is understandable. Link to comment Share on other sites More sharing options...
GeorgieB Posted September 2, 2012 Author Share Posted September 2, 2012 Your english is very good! Thanks for your input Elwira. :) Link to comment Share on other sites More sharing options...
aussiezrule Posted November 15, 2012 Share Posted November 15, 2012 Hi guys :) I recently got Reggie tested for the MDR1 gene mutation (ivemectin sensitivity) and just got the results back now and she is a Carrier only. I've heard conflicting ideas on weather carriers still react to ivermectin and related drugs or not. Does anyone know for certain? The best website I have seen with a list of drugs is www.busteralert.org/ Link to comment Share on other sites More sharing options...
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