Autosomal Recessive Severe Combined Immunodeficiency

[shortstep]

Autosomal recessive Severe Combined Immunodeficiency

http://www.nature.com/gene/journal/vaop/nc...gene20116a.html

SCID gene found in a 'genetically linked group of dogs'.

(FCI name of genetically linked group of dogs' was withheld as I cannot find the breed recogized by ANKC and did not want to offend those who only want to talk about ANKC dogs. However, please see ANKC dog breed below that this disease has been documented in, so as to keep the post about SCID relevent to ANKC dog topics).

Jack Russell and SCID

http://jvdi.org/cgi/reprint/14/3/194.pdf

This disease may be in many breeds of dogs, and could be the cause of fading puppy, still born pups or absorbed pups and may go undiagnosed.

[sandgrubber]

It might be worth posting these links in the General forum under the pinned Studies About Dogs. I'm not great at the science involved, but think it says something significant about:

(a) mutation as affecting genetic problems

(b) problems arising from multiple genes.

I am always glad to see any progress on polygenetic factors . . . I'd guess that HD, OCD, various temperament disorders, and lots of other factors for which genetics seems to be important, but there is no simple/effective genetic test are polygenetic.

Let's hope progress on this rare problem is a harbinger of progress on some of the nagging problems that plague dog breeders.

Autosomal recessive Severe Combined Immunodeficiency

http://www.nature.com/gene/journal/vaop/nc...gene20116a.html

SCID gene found in a 'genetically linked group of dogs'.

(FCI name of genetically linked group of dogs' was withheld as I cannot find the breed recogized by ANKC and did not want to offend those who only want to talk about ANKC dogs. However, please see ANKC dog breed below that this disease has been documented in, so as to keep the post about SCID relevent to ANKC dog topics).

Jack Russell and SCID

http://jvdi.org/cgi/reprint/14/3/194.pdf

This disease may be in many breeds of dogs, and could be the cause of fading puppy, still born pups or absorbed pups and may go undiagnosed.