Stitch Posted June 28, 2010 Share Posted June 28, 2010 Does anyone know if these drugs are used for the same purposes in veterinary science as they are in human medicine? Link to comment Share on other sites More sharing options...
Rappie Posted June 28, 2010 Share Posted June 28, 2010 (edited) Amitriptyline is a tricyclic anti-depressant (TCA), it is used in veterinary medicine to treat anxiety based behavioural disorders and the occasionally some medical condition and chronic pain. Newer drugs like fluoxetine and clomipramine (Reconcile / Prozac and Clomicalm) tend to be used more frequently for behavioural management Edited June 28, 2010 by Rappie Link to comment Share on other sites More sharing options...
Stitch Posted June 28, 2010 Author Share Posted June 28, 2010 (edited) Endep & Deptran (doxypin) are human anti-depressant drugs, which are also used to assist with chronic pain, pain from muscle spasms because of their ability to relax muscles, and with associated sleep deprivation problems. They are considered to be non-addictive and can be interchangeable with each other which is why I asked. Edited June 28, 2010 by STITCH Link to comment Share on other sites More sharing options...
Rappie Posted June 28, 2010 Share Posted June 28, 2010 Doxepin is used for psychogenic dermatoses, it's not used much for other behavioural issues. Link to comment Share on other sites More sharing options...
Stitch Posted June 28, 2010 Author Share Posted June 28, 2010 Do you know why? Especially as in human applications the two drugs are an alternative to one another. Link to comment Share on other sites More sharing options...
Rappie Posted June 28, 2010 Share Posted June 28, 2010 Do you know why?Especially as in human applications the two drugs are an alternative to one another. Differences in efficacy and bioavailability I suppose. The drugs are metabolised differently in dogs and cats compared to humans. Doxepin has antihistamine effect as well it's other effect on brain chemistry - hence why it might be used in dogs who either have anxiety issues AND a skin complaint (as some antihistamines cannot be used with drugs like Clomicalm) or whose skin issues have a basis in anxiety such as acral lick granulomas with an OCD component. Link to comment Share on other sites More sharing options...
Stitch Posted June 28, 2010 Author Share Posted June 28, 2010 Hmmm, very interesting! Thank you for your feedback. Link to comment Share on other sites More sharing options...
PuddleDuck Posted June 29, 2010 Share Posted June 29, 2010 I'm not sure from a canine perspective :D but endep is brilliant drug for managing chronic pain. I wouldn't consider it to be an easily interchangeable drug though, you really have to be weaned off it slowly. Link to comment Share on other sites More sharing options...
Stitch Posted June 29, 2010 Author Share Posted June 29, 2010 Agreed, but Doxepin is used for the same thing in humans however in animals it seems that Endep is the preferred method. Both have to be discontinued gradually - they are classed as non-addictive however there is definitely a withdrawal period. Link to comment Share on other sites More sharing options...
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