Question Regarding Vaccinations...

[Cathaven]

I had two of my guys titer tested yesterday and then gave them the KC nasal for KC cover. Below is a link to the vet that did it and they have some great info on their site about the new 3 year regime.

http://www.animaloptions.com.au/index.php?...ot-to-vaccinate

Thanks wherezaball for that info. I have just emailed the link that you provided in regard to vaccinations and will definetly be going via titer levels. Personally unless your furfriend is going into kennels I err on the side of caution with all these vaccinations......I also have a little 11yr old and will certainly not be getting him vaccinated.

In fact I have a lovely old cat (rescued stray) that at some time had cat flu in his life and wasn't treated so has damaged mucous membranes. My vet actually recommended not to vaccinate him, rather dose him up on raw food and lysine, so I am pleased to say that my vet sees the big picture......

cheers Cathaven

[Kelly_Louise]

Stormie, Im in the Liverpool/Moorebank area of Sydney. We walk around a bushy lake area that is very highly populated with people walking their dogs (hence how she got KC a couple of times this year) and some we know and will stop and have a play with. We have dogs on either side of us, but they 'appear' to be well cared for. We also go to obedience training fairly regularly (more for socialisation than anything) and there are sometimes new dogs that have recently come from the pound or rescue. Other than that, Sash doesn't come into contact with too many other dogs. Does that help?

I'll be doing lots of research this week... and perhaps ringing some different vets etc. I'm not sure whether I'll truly understand it all, but I'll try

Thanks for your help guys!

[Jumabaar]

Stormie, Im in the Liverpool/Moorebank area of Sydney. We walk around a bushy lake area that is very highly populated with people walking their dogs (hence how she got KC a couple of times this year) and some we know and will stop and have a play with. We have dogs on either side of us, but they 'appear' to be well cared for. We also go to obedience training fairly regularly (more for socialisation than anything) and there are sometimes new dogs that have recently come from the pound or rescue. Other than that, Sash doesn't come into contact with too many other dogs. Does that help?

I'll be doing lots of research this week... and perhaps ringing some different vets etc. I'm not sure whether I'll truly understand it all, but I'll try :D

Thanks for your help guys!

Oooh you are near me

I would recomend Dr Anthony Chu if you want a mobile vet. I go to All Natural Vet Care at Russel Lea where he also works but I know of a few ppl that have him visit their homes (not sure on price)http://www.activet.com.au/history.shtml

He was really good about vaccinations and I know he is up to date with all the information. He advised me when I had a sick 6wk old pup (that I bred) what to do regarding vaccintion and I am happy to say she is very healthy now (my local vets were waiting for me to PTS). He does holistic (both western and alternate) veterinary medicine. I know the clinic does titre testing for memory it was about $80 + consult but I usually get half an hour to an hour for a consult! Abby was giving a 'regular annual' vac two yrs ago and her titres are still normal. She does flyball, obedience, herding and showing so is in contact with a lot of dogs.

And he is really nice/easy to talk to!! and he was also very gentle with my dogs.

Good luck

ETA- he will take the time to really explain it all to you!!

Edited October 5, 2009 by woofenpup

[Jed]

There is some evidence out there that dogs who are vaccinated annually are more prone to contracting parvo.

Where?

Honest question, because I've looked, and I haven't yet found it.

Give me a few days, and I'll dig it up for you. Catherine O'Driscoll? Bob Rogers? Dunno, forgotten. I got interested in this some years ago (10 - 12??) - a friend who is a vet nearly lost her 7 year old staffy to parvo, when she bought hooe a pup which was incubating parvo. Saffy had been anually vaccinated.

Had a really good discussion with another vet who had some theories why some vac pups got parvo and some not, and he wondered whether the annual vaccinations "cancelled" each other out. I was then interested to find out if that was the case, because my dogs only had 3 vacs and we had a few pups visit with parvo (not mine) and none of mine caught anything.

But it WAS a staffy, and they are more prone. I always remembered that discussion, and years later, I found out a lot more about it. And it's stuck with me. I'll find it for you, it's probably in my favourites, but there are a lot of them. And it would have references, because I tend not to believe everything I read on the web, old cynic I am!! But it was years ago I read it too, so I've forgotten the salient details. It might even be on here somewhere, with references, so I'll check there too.

[sas]

I didn't even know C7 exsisted, that's pretty extreme!

As with others I reccomend doing a bit more research before getting your old girl vaccinated again, maybe get the Titre tests, she may not even need the vaccination.

[Erny]

Following is a "copy/paste" of Dr. Jean Dodd's latest handout on vaccines, for those interested. Sorry - it makes for a long post.

[c]VACCINE ISSUES REVISITED

W. Jean Dodds, DVM[/c]

BACKGROUND

There is little doubt that application of modern vaccine technology has permitted us to protect companion animals effectively against serious infectious diseases.

Viral disease and recent vaccination with single or combination modified live-virus (MLV) canine vaccines, especially those containing distemper virus, adenovirus 1 or 2, and parvovirus are increasingly recognized contributors to immune-mediated blood disease, bone marrow failure, and organ dysfunction. Potent adjuvanted killed vaccines like those for rabies virus also can trigger immediate and delayed adverse vaccine reactions in any species (vaccinosis). Genetic predisposition to these disorders in humans has been linked to the leucocyte antigen D-related gene locus of the major histocompatibility complex, and is likely to have parallel associations in domestic animals.

It should be appreciated , however, that we can question conventional vaccine regimens and adopt effective and safe alternatives today primarily because the risk of disease has been significantly reduced by the widespread use of vaccination programs, which convey underlying population or herd immunity.

ADVERSE EVENTS ASSOCIATED WITH VACCINATION

The clinical signs associated with vaccine reactions typically include fever, stiffness, sore joints and abdominal tenderness, susceptibility to infections, neurological disorders and encephalitis, collapse with autoagglutinated red blood cells and icterus (autoimmune hemolytic anemia, AIHA, also called immune-mediated hemolytic anemia, IMHA), or generalized petechiae and ecchymotic hemorrhages (immune-mediated thrombocytopenia , ITP). Hepatic enzymes may be markedly elevated, and liver or kidney failure may occur by itself or accompany bone marrow suppression.

Furthermore, MLV vaccination has been associated with the development of transient seizures in puppies and adult dogs of breeds or cross-breeds susceptible to immune-mediated diseases especially those involving hematologic or endocrine tissues (e.g. AIHA, ITP, autoimmune thyroiditis). Post-vaccinal polyneuropathy is a recognized entity associated occasionally with the use of distemper, parvovirus, rabies and presumably other vaccines. This can result in various clinical signs including muscular atrophy, inhibition or interruption of neuronal control of tissue and organ function, muscular excitation, inco-ordination and weakness, as well as seizures.

Certain breeds or families of dogs appear to be more susceptible to adverse vaccine reactions, particularly post-vaccinal seizures, high fevers, and painful episodes of hypertrophic osteodystrophy (HOD). Therefore, we have the responsibility to advise companion animal breeders and caregivers of the potential for genetically susceptible littermates and relatives to be at increased risk for similar adverse vaccine reactions. In popular (or rare) inbred and line-bred animals, the breed in general can be at increased risk as illustrated in the examples below.

Polyvalent MLV vaccines which multiply in the host elicit a stronger antigenic challenge to the animal and should mount a more effective and sustained immune response. However, this can overwhelm the immunocompromised or even a healthy host that has ongoing exposure to other environmental stimuli as well as a genetic predisposition that promotes adverse response to viral challenge. The recently weaned young puppy or kitten being placed in a new environment may be at particular risk. Furthermore, while the frequency of vaccinations is usually spaced 2-3 weeks apart, some veterinarians have advocated vaccination once a week in stressful situations; a practice makes little sense scientifically or medically.

An augmented immune response to vaccination is seen in dogs with pre-existing inhalant allergies (atopy) to pollens. Furthermore, the increasing current problems with allergic and immunological diseases have been linked to the introduction of MLV vaccines more than 20 years ago. While other environmental factors no doubt have a contributing role, the introduction of these vaccine antigens and their environmental shedding may provide the final insult that exceeds the immunological tolerance threshold of some individuals in the pet population. The accumulated evidence indicates that vaccination protocols should no longer be considered as a “one size fits all” program.

In cats, while adverse vaccine reactions may be less common, aggressive tumors (fibrosarcomas) can occasionally arise at the site of vaccination. A recent study from Italy reported finding similar tumors in dogs at the injection sites of vaccinations (Vascellari et al, 2003). These investigators stated that their “study identified distinct similarities between canine fibrosarcomas from presumed injection sites and feline post-vaccinal fibrosarcomas, suggesting the possibility of the development of post-injection

sarcomas not only in cats, but also in dogs”.

Additionally, vaccination of pet and research dogs with polyvalent vaccines containing rabies virus or rabies vaccine alone was shown to induce production of antithyroglobulin autoantibodies, a provocative and important finding with implications for the subsequent development of hypothyroidism (Scott-Moncrieff et al, 2002).

For these special cases, appropriate alternatives to current vaccine practices include:

1) measuring serum antibody titers;

2) avoidance of unnecessary vaccines or over vaccinating;

3) caution in vaccinating sick or febrile individuals; and

4) tailoring a specific minimal vaccination protocol for dogs of breeds or families known to be at increased risk for adverse reactions.

5) considerations include starting the vaccination series later, such as at nine or ten weeks of age when the immune system is more able to handle antigenic challenge;

6) alerting the caregiver to pay particular attention to the puppy’s behavior and overall health after the second or subsequent boosters; and

7) avoiding revaccination of individuals already experiencing a significant adverse event. Littermates of affected puppies should be closely monitored after receiving additional vaccines in a puppy series, as they too are at higher risk.

SEROLOGIC VACCINE TITER TESTING

Some veterinarians have challenged the validity of using vaccine titer testing to assess the immunologic status of animals against the common, clinically important infectious diseases.

With all due respect, this represents a misunderstanding of what has been called the “fallacy of titer testing”, because research has shown that once an animal’s titer stabilizes it is likely to remain constant for many years. Properly immunized animals have sterilizing immunity that not only prevents clinical disease but also prevents infection, and only the presence of antibody can prevent infection. As stated by eminent expert Dr. Ronald Schultz in discussing the value of vaccine titer testing, these tests “show that an animal with a positive test has sterilizing immunity and should be protected from infection. If that animal were vaccinated it would not respond with a significant increase in antibody titer, but may develop a hypersensitivity to vaccine components (e.g. fetal bovine serum). Furthermore, the animal doesn't need to be revaccinated and should not be revaccinated since the vaccine could cause an adverse reaction (hypersensitivity disorder). You should avoid vaccinating animals that are already protected. It is often said that the antibody level detected is “only a snapshot in time". That's simply not true; it is more a “motion picture that plays for years".

Furthermore, protection as indicated by a positive titer result is not likely to suddenly drop-off unless an animal develops a medical problem such as cancer or receives high or prolonged doses of immunosuppressive drugs. Viral vaccines prompt an immune response that lasts much longer than that elicited by classic antigen. Lack of distinction between the two kinds of responses may be why practitioners think titers can suddenly disappear.

But, not all vaccines produce sterilizing immunity. Those that do include: distemper virus, adenovirus, and parvovirus in the dog, and panleukopenia virus in the cat. Examples of vaccines that produced non-sterile immunity would be leptospirosis, bordetella, rabies virus, herpesvirus and calicivirus --- the latter two being upper respiratory viruses of cats. While non-sterile immunity may not protect the animal from infection, it should keep the infection from progressing to severe clinical disease.

Therefore, interpreting titers correctly depends upon the disease in question. Some titers must reach a certain level to indicate immunity, but with other agents like those that produce sterile immunity, the presence of any measurable antibody shows protection. The positive titer test result is fairly straightforward, but a negative titer test result is more difficult to interpret, because a negative titer is not the same thing as a zero titer and it doesn't necessarily mean that animal is unprotected. A negative result usually means the titer has failed to reach the threshold of providing sterile immunity. This is an important distinction, because for the clinically important distemper and parvovirus diseases of dogs, and panleukopenia of cats, a negative or zero antibody titer indicates that the animal is not protected against canine parvovirus and may not be protected against canine distemper virus or feline panleukopenia virus.

Finally, what does more than a decade of experience with vaccine titer testing reveal ? Published studies in refereed journals show that 90-98% of dogs and cats that have been properly vaccinated develop good measurable antibody titers to the infectious agent measured. So, in contrast to the concerns of some practitioners, using vaccine titer testing as a means to assess vaccine-induced protection will likely result in the animal avoiding needless and unwise booster vaccinations.

Our recent study (Twark and Dodds, 2000), evaluated 1441 dogs for CPV antibody titer and 1379 dogs for CDV antibody titer. Of these, 95.1 % were judged to have adequate CPV titers, and nearly all (97.6 %) had adequate CDV titers. Vaccine histories were available for 444 dogs (CPV) and 433 dogs (CDV). Only 43 dogs had been vaccinated within the previous year, with the majority of dogs (268 or 60%) having received a booster vaccination 1-2 years beforehand. On the basis of our data, we concluded that annual revaccination is unnecessary. Similar findings and conclusions have been published recently for dogs in New Zealand (Kyle et al, 2002), and cats (Scott and Geissinger, 1999; Lappin et al, 2002). Comprehensive studies of the duration of serologic response to five viral vaccine antigens in dogs and three viral vaccine antigens in cats were recently published by researchers at Pfizer Animal Health (Mouzin et al, 2004).

When an adequate immune memory has already been established, there is little reason to introduce unnecessary antigen, adjuvant, and preservatives by administering booster vaccines. By titering annually, one can assess whether a given animal’s humoral immune response has fallen below levels of adequate immune memory. In that event, an appropriate vaccine booster can be administered.

OTHER ISSUES WITH OVER VACCINATION

Other issues arise from over vaccination, as the increased cost in time and dollars spent needs to be considered, despite the well-intentioned solicitation of clients to encourage annual booster vaccinations so that pets also can receive a wellness examination. Giving annual boosters when they are not necessary has the client paying for a service which is likely to be of little benefit to the pet’s existing level of protection against these infectious diseases. It also increases the risk of adverse reactions from the repeated exposure to foreign substances.

COMPLIANCE OR RESISTENCE TO CURRENT VACCINE GUIDELINES ?

For more than a decade, the issues discussed above on overvaccination and vaccine safety for companion animals have been raised by vaccinologists and veterinary clinicians. But, how has this still controversial knowledge impacted the veterinary profession and pet owner today? Have veterinarians really embraced the national policies on vaccination guidelines? Does the public trust veterinarians to be up-to-date on these issues or are they unsure? Do they believe veterinarians have a conflict of interest if they seek the income from annual booster vaccinations? Given media information regarding autism and measles vaccination, the public is more aware and worried about vaccine safety.

Some veterinarians today still tell their clients there is no scientific evidence linking vaccinations with adverse effects and serious illness. This is ignorance, and confuses an impressionable client. On the other hand, vaccine zealots abound with hysteria and misinformation. None of these polarized views is helpful.

Veterinarians are still routinely vaccinating ill dogs and those with chronic diseases or prior adverse vaccine reactions. This is especially problematic for rabies boosters, as many colleagues believe they have no legal alternative, even though the product label states it's intended for healthy animals. See www.rabieschallengefund.org

NEW BREAKTHROUGHS

Failure to standardize the legal mandate for rabies vaccinations nationwide is medically and scientifically unwarranted. The fact that individual states, counties and cities elect to mandate annual rabies boosters despite federally licensed three-year rabies vaccines is misguided.

Now that Arkansas and Rhode Island have passed new rabies laws authorizing a 3-year rabies protocol for dogs and cats, Alabama remains the only state that still requires them to be vaccinated annually against rabies. But this state is in the process of changing to three years as well. However, some individual cities and counties (e.g. Bell County, TX) still require annual rabies booster vaccination. For Cheyenne, WY and Wichita, KS, pressure from the public and the local veterinary associations effected a recent change to every three years.

Despite these recent changes, the practice of rabies booster vaccination in these states and local areas has been left as optional at the discretion of the client’s veterinarian. So this is a Catch-22 situation, because if the veterinarian still believes the rabies booster should be given annually instead of as licensed, they usually can talk their client into doing so.

RABIES VACCINES AND THE USDA/CVB

Rabies vaccines are the most common group of biological products identified in adverse event reports received by the USDA’s Center for Veterinary Biologics (CVB). Currently, 14 rabies vaccines are labeled for use in dogs. These vaccines must meet the standard requirements established in the Title 9 Code of Federal Regulations. This requires that the vaccine provide a protected fraction of ≥ 83% when comparing vaccinated animals versus control animals. Also, all rabies vaccines are evaluated for safety prior to licensure, which includes performance of a field safety trial. Additionally, each serial of rabies vaccine is tested for potency by use of the National Institutes of Health potency test or another test approved by the CVB, and is tested for safety in the host and laboratory animals.

Safety Review

Before licensure, a product must be shown to be safe through a combination of safety evaluations. The field safety trial is the most comprehensive evaluation and has the objective of assessing the safety of the product in its target population under the conditions of its intended use. However, safety studies before licensure may not detect all safety concerns for a number of reasons, as follows: insufficient number of animals for low frequency events, insufficient duration of observation, sensitivities of subpopulations (eg, breed, reproductive status, and unintended species), or interactions with concomitantly administered products.

State and Local Authority for Rabies Control Programs

Although the CVB licenses veterinary biological products for use in the prevention of rabies, it is the state and local authorities govern and administer their respective rabies animal control programs. Some of these programs allow exemptions to the vaccination requirements, if medical concerns exist related to potential adverse events, but more commonly, others do not allow exemptions, regardless of the justification.

REPORTING ADVERSE VACCINE REACTIONS

There is no mandatory reporting of adverse reactions in veterinary medicine. The 2007 World Small Animal Veterinary Association (WSAVA) Vaccine Guidelines states that there is: "gross under-reporting of vaccine-associated adverse events which impedes knowledge of the ongoing safety of these products." http://www.wsava.org/SAC.htm,

Even in humans, where mandatory reporting of adverse vaccine reactions is required, Dr. David Kessler, former head of the Food & Drug Administration, reported that "only about 1% of serious events are reported to the FDA". [JAMA .269:.2785, 1993]. This problem of under-reporting has persisted for many years.

Despite the serious under-reporting of vaccinal adverse reactions, the 2008 Report from the USDA’s CVB [JAVMA 232:1000-1002, 2008], states that between April 1, 2004 and March 31, 2007, they "requested manufacturers of rabies vaccines to provide adverse event report summaries for their products. During this period, nearly 10,000 adverse event reports (all animal species) were received by manufacturers of rabies vaccines. Approximately 65% of the manufacturer's reports involved dogs."

The USDA/CVB 2008 Report further states that "Rabies vaccines are the most common group of biological products identified in adverse event reports received by the CVB." During the 3-year period covered in this report, the CVB received 246 adverse event reports for dogs in which a rabies vaccine was identified as one of the products administered. Reports were assessed for causality, and of these:

217 reports were considered possibly related to ≥ 1 of the vaccines given, 7 were considered unlikely, and 22 were assessed as unknown. Of reports with age information (n = 206), 21.4% of the dogs were ≤ 6 months old, 33.5% were > 6 months old but ≤ 2 years old, and 45.1% were > 2 years old. Of reports with sex information (n = 209), 54.5% of the dogs were female.

The following clinical terms were listed “to describe possibly related adverse events in dogs vaccinated against rabies “ and reported to the USDA/CVB between April 1, 2004-March 31, 2007. For 217 adverse event reports – the clinical term is followed by the % of dogs affected:

Vomiting-28.1%; facial swelling-26.3%; injection site swelling or lump-19.4%; lethargy-12%; urticaria-10.1%; circulatory shock-8.3%; injection site pain-7.4%; pruritus-7.4%; injection site alopecia or hair loss-6.9%; death-5.5%; lack of consciousness-5.5; diarrhea-4.6%; hypersensitivity (not specified)-4.6%; fever-4.1%;, anaphylaxis-2.8%; ataxia-2.8%; lameness-2.8%; general signs of pain-2.3%; hyperactivity-2.3%; injection site scab or crust-2.3%;, muscle tremor-2.3%; tachycardia-2.3%; and thrombocytopenia-2.3%.

The overall adverse report rate for rabies vaccines was determined to be 8.3 reports/100,000 doses sold. Adverse events considered possibly related to vaccination included acute hypersensitivity (59%); local reactions (27%); systemic reactions, which refers to short-term lethargy, fever, general pain, anorexia, or behavioral changes, with or without gastrointestinal disturbances starting within 3 days after vaccination (9%); autoimmune disorders (3%); and other (2%). In nearly 72% of the dogs of these reports, other vaccine or medicinal products were administered in conjunction with the rabies vaccine. In those instances, it was generally not possible to determine which product or products might be most closely linked to the adverse event. Additionally, in some instances, dogs had > 1 clinical sign, resulting in the coding of several clinical signs in a single report.

But, IF one applied the only 1% estimated reporting figure of "serious" events from the former head of the FDA to the 10,000 adverse events reported for animal rabies vaccines, 65% of which were in dogs, then the actual number of dogs that had adverse reactions to the vaccine could be as high as 650,000 in that 3 year period with 3,575 (5.5%) of the dogs dying from their adverse reaction.

TREATMENT OF VACCINOSIS

The diagnosis of vaccinosis is an exclusionary one -- i.e. nothing will be found upon other testing to explain the symptoms. The animal is given the oral homeopathics, Thuja (for all vaccines other than rabies), and Lyssin to detox the rabies “miasm”. IF there are no holistic veterinarians in the area, these homeopathics can be obtained from www.naturalrearing.com.

Our therapy typically uses steroids in tapering doses over 4-6 weeks to stop the inflammatory process and clinical symptoms. Therapy begins with an injection of dexamethasone phosphate first, and if the animal improves right away, is continued with prednisone at 0.5 mg per pound twice daily for 5-7 days, then tapered gradually over the next month to every other day. The use of steroids will cause an increase in water intake and urination, but the animal should be able to handle the drug at these tapering doses for a few weeks. IF a holistic veterinarian wants to try an alternative therapy to steroids, this approach can also work. Try it for several days to see if it will work.

We advise that these patients receive no further vaccine boosters, except for rabies, where exemption can be sought on a case-by-case basis but may not be granted in the specific locale.

REFERENCES

● American Association of Equine Practitioners, Infectious Disease Committee. Guidelines for the vaccination of horses.Vaccinations for adult horses, 2008. www.aaep.org

● American Association of Equine Practitioners, Infectious Disease Committee. Guidelines for the vaccination of horses Vaccinations for foals, 2008. www.aaep.org

● Carmichael LE. An annotated historical account of canine parvovirus. J Vet Med B, Infect Dis Vet Public Health 52:303-311, 2005.

● Dodds WJ. More bumps on the vaccine road. Adv Vet Med 41:715-732, 1999.

● Dodds WJ. Vaccination protocols for dogs predisposed to vaccine reactions. J Am An Hosp Assoc 38: 1-4, 2001.

● Dodds WJ. Vaccine issues evisited: what’s really happening ? Proc Am Hol Vet Med Assoc, Tulsa, OK, 2007, pp 132-140.

● Dodds WJ. Complementary and alternative veterinary medicine: the immune system. Clin Tech Sm An Pract 17: 58-63, 2002.

● Dodds WJ. Big shots: vaccination series, Parts 1-3. Equine Wellness Magazine, 2007.

● Goodman LB, Wagner B, Flaminio MJ et al. Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1). Vaccine 24:3636-3645, 2006.

● Gore TC, Lakshmanan N, Williams JR, et al. Three-year duration of immunity in cats following vaccination against feline rhinotracheitis virus, feline calicivirus, and feline panleukopenia virus. Vet Therapeutics 7:213-222, 2006.

● Hogenesch H, Azcona-Olivera J, Scott-Moncreiff C, et al. Vaccine-induced autoimmunity in the dog. Adv Vet Med 41: 733-744, 1999.

● Hustead DR, Carpenter T, Sawyer DC, et al. Vaccination issues of concern to practitioners. J Am Vet Med Assoc 214: 1000-1002, 1999.

● Kyle AHM, Squires RA, Davies PR. Serologic status and response to vaccination against canine distemper (CDV) and canine parvovirus (CPV) of dogs vaccinated at different intervals. J Sm An Pract, June 2002.

● Lappin MR, Andrews J, Simpson D, et al. Use of serologic tests to predict resistance to feline herpesvirus 1, feline calicivirus, and feline parvovirus infection in cats. J Am Vet Med Assoc 220: 38-42, 2002.

● Larson LJ, Schultz RD. Effect of vaccination with recombinant canine distemper virus vaccine immediately before exposure under shelter-like conditions . Vet Therapeutics 7: 113-118, 2006.

● Larson, LJ, Schultz, RD. Do current canine parvovirus vaccines provide protection from the new CPV-2c variant ? Vet. Therapeutics 9 (2): 94-101, 2008.

● McGaw DL, Thompson M, Tate, D, et al. Serum distemper virus and parvovirus antibody titers among dogs brought to a veterinary hospital for revaccination. J Am Vet Med Assoc 213: 72-75, 1998.

● Moore GE, Glickman LT. A perspective on vaccine guidelines and titer tests for dogs. J Am Vet Med Assoc 224: 200-203. 2004.

● Moore et al, Adverse events diagnosed within three days of vaccine administration in dogs. J Am Vet Med Assoc 227:1102–1108, 2005.

● Mouzin DE, Lorenzen M J, Haworth, et al. Duration of serologic response to five viral antigens in dogs. J Am Vet Med Assoc 224: 55-60, 2004.

● Mouzin DE, Lorenzen M J, Haworth, et al. Duration of serologic response to three viral antigens in cats. J Am Vet Med Assoc 224: 61-66, 2004.

● Paul MA.Credibility in the face of controversy. Am An Hosp Assoc Trends Magazine XIV(2):19-21,1998.

● Paul MA (chair) et al. Report of the AAHA Canine Vaccine Task Force: 2003 canine vaccine guidelines, recommendations, and supporting literature. AAHA, April 2003, 28 pp.

● Paul MA (chair) et al. Report of the AAHA Canine Vaccine Task Force : 2006 AAHA Canine Vaccine Guidelines. J Am An Hosp Assoc 42:80-109, Mar-April 2006, 28 pp. www.aahanet.org

● Schultz RD. Current and future canine and feline vaccination programs. Vet Med 93:233-254, 1998.

● Schultz RD Conklin S. The immune system and vaccines. Comp Cont Educ Pract Vet 20, 5-18.1998.

● Schultz R D Considerations in designing effective and safe vaccination programs for dogs. In: Carmichael LE (editor), Recent Advances in Canine Infectious Diseases. IVIS, 2000. www.ivis.org.

● Schultz RD, Ford RB, Olsen J, Scott F. Titer testing and vaccination: a new look at traditional practices. Vet Med, 97: 1-13, 2002 (insert).

● Schultz RD. Duration of immunity for canine and feline vaccines: a review. Vet Microbiol 117:75-79, 2006.

● Scott FW, Geissinger CM. Long-term immunity in cats vaccinated with an inactivated trivalent vaccine. Am J Vet Res 60: 652-658, 1999.

● Scott-Moncrieff JC, Azcona-Olivera J, Glickman NW, et al. Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs. J Am Vet Med Assoc 221: 515-521, 2002.

● Smith CA. Are we vaccinating too much? J Am Vet Med Assoc 207:421-425, 1995.

● Tizard I, Ni Y. Use of serologic testing to assess immune status of companion animals. J Am Vet Med Assoc 213: 54-60, 1998.

● Twark L, Dodds WJ. Clinical application of serum parvovirus and distemper virus antibody titers for determining revaccination strategies in healthy dogs. J Am Vet Med Assoc 217:1021-1024, 2000.

● Vascellari M, Melchiotti E, Bozza MA et al. Fibrosarcomas at presumed sites of injection in dogs: characteristics and comparison with non-vaccination site fibrosarcomas and feline post-vaccinal firosarcomas. J Vet Med 50 (6): 286-291, 2003.

CANINE VACCINE ADVERSE EVENTS *

• retrospective cohort study; 1.25 million dogs vaccinated at 360 veterinary hospitals

• 38 adverse events per 10,000 dogs vaccinated

• inversely related to dog weight

• vaccines prescribed on a 1-dose-fits-all basis, rather than by body weight.

• increased for dogs up to 2 yr of age, then declined

• greater for neutered versus sexually intact dogs

• increased as number of vaccines given together increased

• increased after the 3 rd or 4 th vaccination

• genetic predisposition to adverse events documented

____________________________________________________________

_

* from Moore et al, JAVMA 227:1102–1108, 2005

VACCINE CONCLUSIONS FOR CANINES *

Factors that increase risk of adverse events 3 days after vaccination:

• young adult age

• small-breed size

• neutering

• multiple vaccines given per visit

These risks should be communicated to clients

_______________________________________________________

* from Moore et al, JAVMA 227:1102–1108, 2005

FELINE VACCINE ADVERSE EVENTS *

• retrospective cohort study; 0.5 million cats vaccinated at 329 veterinary hospitals

• 51.6 adverse events per 10,000 cats vaccinated

• inversely related to cat weight

• increased for cats about 1 yr of age

• greater for neutered versus sexually intact cats

• increased as number of vaccines given together increased

• Lethargy with or without fever was most common sign

_________________________________________________

* from Moore et al, JAVMA 231:94-100, 2007

VACCINE CONCLUSIONS FOR FELINES *

Factors that increase risk of adverse events 30 days after vaccination:

• young adult age

• neutering

• multiple vaccines given per visit

These risks should be communicated to clients, and the number

of vaccines administered concurrently limited

_______________________________________________________

* from Moore et al, JAVMA 231:94-100, 2007

FREQUENTLY ASKED QUESTIONS *

Q. Is there risk of overvaccinating with vaccines not needed for a specific animal ?

A. Yes. Vaccines contain material designed to challenge the immune system of the pet, and so can cause adverse reactions. They should not be given needlessly, and should be tailered to the pet’s individual needs.

Q. Are the initial series of puppy core vaccines immunosuppressive ?

A. Yes. This period of immuno suppression from MLV canine distemper and hepatitis vaccines coincides with the time of vaccine-induced viremia, from days 3 to 10 after vaccination.

Q. Can smaller doses of vaccines be given to toy dog breeds ?

A. Yes, they can, although some vaccinologists believe that the whole amonut should be given because it represents the minimum immunizing dose. My view is that a half dose of vaccines, other than rabies, as required by law, should suffice and would be safer.

Q. Can anesthetized patients be vaccinated ?

A. This is not preferred, because a hypersensitivity reaction with vomiting and aspiration could occur and anesthetic agents can be immunomodulating.

Q. Is it safe to vaccinate pregnant pets ?

A. Absolutely not.

Q. Should pets with immunosuppressive diseases such as cancer or autoimmune diseases, or adverse vaccine reactions/ hypersensitibvity receive booster vaccinations ?

A. No. Vaccination with MLV products should be avoided as the vaccine virus may cause disease; vaccination with killed products may aggravate the immune-mediated disease or be ineffective. For rabies boosters that are due, local authorities may accept titers instead.

Q. If an animal receives immunosuppressive therapy, how long afterwards can the pet safely be vaccinated ?

A. Wait at least 2 weeks.

Q. Should vaccines be given more often that 2 weeks apart even if a different vaccine is being given ?

A. No. The safest and most effective interval is 3-4 weeks apart.

Q. At what age should the last vaccine dose be given in the puppy and kitten series ?

A. The last dose of vaccine should be given between 14-16 weeks. Rabies vaccine should preferably be given separately as late as possible under the law (e.g. 20-24 weeks).

Q. Can intranasal Bordetella vaccine be given parenterally ?

A. No. The vaccine can cause a severe local reaction and may even kill the pet.

Q. Will a killed parenteral Bordetella vaccine given intranasally produce immunity ?

A. No.

Q. Can MLV parenteral vaccines for cats be used intranasally ?

A. Never. Any mucosal (e.g. conjunctival and nasal) contact with these vaccines can cause disease.

Q. Are homeopathic nosodes capable of immunizing pets ?

A. No. There is no scientific documentation that nosdoes protect against infectious diseases of pets. The one parvovirus nosode trial conducted years ago did not protect against challenge.

Q. Should disinfectant be used at the vaccine injection site?

A. No. Disinfectants could inactivate a MLV product.

Q. Can vaccines cause autoimmune diseases?

A. Vaccines themselves do not cause these diseases, but they can trigger autoimmune responses followed by disease in genetically predisposed animals, as can any infection, drug, or chemical / toxic exposures etc.

Q. Can a single vaccine dose provide any benefit to the dog or cat? Will it benefit the canine and feline populations?

A. Yes. One dose of a MLV canine or feline core vaccine should provide long term immunity when given to animals at or after 16 weeks of age. Every puppy and kitten 16 weeks of age or older should receive at least one dose of the MLV core vaccines. We need to vaccinate more animals in the population with core vaccines to achieve herd immunity (e.g. 75% or higher, when probably only 50% of dogs and 25% of cats are vaccinated) and thereby prevent epidemic outbreaks.

Q. If an animal receives only the first dose of a vaccine that needs two doses to immunize, will it have immunity ?

A. No. A single dose of a two-dose vaccine like Leptospirosis or feline leukemia vaccine will not provide immunity. The first dose is for priming the immune system. The second for boosting the immunity has to be given within 6 weeks; otherwise the series has to start over again. After those two doses, revaccination with a single dose can be done at any time.

Q. Can maternally derived antibodies (MDA) also block immunity to killed vaccines and prevent active immunization with MLV vaccines ?

A. Yes. MDA can block certain killed vaccines, especially those that require two doses to immunize. With MLV vaccines, two doses are often recommended, particularly in young animals, to be sure one is given beyond the neutralizing period of MDA.

Q. How long after vaccination does an animal develop immunity that will prevent severe disease when the core vaccines are used?

A. This is dependent on the animal, the vaccine, and the disease.

• The fastest immunity is provided by CDV vaccines -- MLV and recombinant canarypox virus vectored. The immune response starts within mins - hrs and provides protection within a day without interference from MDA.

• Immunity to CPV-2 and FPV develops after 3-5 days when an effective ML V vaccine is used. In contrast, killed FPV-2 vaccine often takes 2 - 3 wks or longer to provide protective immunity.

• CAV-2 MLV given parenterally provides immunity against CAV-1 in 5 to 7 days.

• Time from vaccination to immunity is difficult to determine for FCV and FHV-1 because some animals will not develop any immunity.

Q. Can dogs and cats be “non-responders” and fail to develop an immune response to vaccines ?

A. Yes. This is a genetic characteristic seen particularly in some breeds or dog families. Boosting them regularly will not produce measurable ciculating immunity, but they may be protected against disease by their cell-mediated and secretory immunity.

Q. Are there parvovirus and distemper virus field mutants that are not adequately protected by current MLV vaccines ?

A. No. All the current CPV-2 and CDV vaccines provide protection from all known viral isolates, when tested experimentally as well as in the field. The current CPV-2 and CPV-2b vaccines provide both short and long term protection from challenge by the CPV-2c variant.

Q. Are serum antibody titres useful in determining vaccine immunity?

A. Yes. They are especially useful for CDV, CPV-2 and CAV-1 in the dog, FPV in the cat, and rabies virus in the cat and dog. Rabies titers, however, are often not acceptable to exempt individual animals from mandated rabies boosters in spite of medical justifcation. Serum antibody titers are of limited or no value for the other vaccines.

* Excerpted from : J Sm An Pract 48, 528–541, 2007.

[Staranais]

There is some evidence out there that dogs who are vaccinated annually are more prone to contracting parvo.

Where?

Honest question, because I've looked, and I haven't yet found it.

Give me a few days, and I'll dig it up for you. Catherine O'Driscoll? Bob Rogers? Dunno, forgotten. I got interested in this some years ago (10 - 12??) - a friend who is a vet nearly lost her 7 year old staffy to parvo, when she bought hooe a pup which was incubating parvo. Saffy had been anually vaccinated.

Had a really good discussion with another vet who had some theories why some vac pups got parvo and some not, and he wondered whether the annual vaccinations "cancelled" each other out. I was then interested to find out if that was the case, because my dogs only had 3 vacs and we had a few pups visit with parvo (not mine) and none of mine caught anything.

But it WAS a staffy, and they are more prone. I always remembered that discussion, and years later, I found out a lot more about it. And it's stuck with me. I'll find it for you, it's probably in my favourites, but there are a lot of them. And it would have references, because I tend not to believe everything I read on the web, old cynic I am!! But it was years ago I read it too, so I've forgotten the salient details. It might even be on here somewhere, with references, so I'll check there too.

Thanks v. much, would really appreciate it. Had to write an essay about canine vaccine side effects/duration of immunity earlier this year and didn't come up with anything like that, but could have missed it - there was lots to read.

And yes, references are a must for me too. I have heard so many completely made-up "facts" about canine and feline vaccination, the whole subject is rather like Chinese Whispers!